Synthesis and Characterization of Carborane-Functionalized Hyperbranched Polyester

The purpose of this study is to synthesize new boron containing carrier compound for Boron Neutron Capture Therapy (BNCT) which two-component radiation therapy method that especially promising the treatment brain tumors and being actively researched in many countries. For research hyperbranched polyester (HBP), bifunctional p-carborane carborane-functionalized HBP were synthesized. Dipentaerythritol was chosen as a core molecule esterified with dimethylol propionic acid. Observed characteristic ester bands OH stretching band FTIR spectrum methyl & methylene peaks 1H NMR indicated synthesis done successfully. A bifunctionalized an acid group benzyl ether protected alcohol prepared three-step reactions. As result these reactions, produced 60% yield. Then, p-carborane. characterization synthesized compounds determined by spectra. confirmed disappearance HBP's groups B-H observed addition, appearance proton signals core, carborane linker peripheral-protecting 1H-NMR spectrum. Finally, water-soluble carborane-containing HB carrying atoms should be served potential BNCT agents.